Fredrik J. Swartling

Identification of an epigenetically and phenotypically distinct peritumoral glioblastoma cell population linked to inferior patient outcome

The paper identifies a distinct peritumoral glioblastoma cell population with unique epigenetic and phenotypic features associated with poor patient outcomes.

Childhood brain tumours instruct cranial haematopoiesis and immunotolerance

This study identifies a mechanism by which skull bone marrow-derived HSPCs and CD4+ T cells promote immunotolerance in childhood brain tumours, showing that antibody therapy targeting CSF cytokines can disrupt this process and induce tumour regression.

Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples

This paper introduces FFPE-ATAC, a method for profiling chromatin accessibility in formalin-fixed paraffin-embedded tissues, demonstrating its effectiveness with colorectal cancer samples.

Perturbation-based gene regulatory network inference to unravel oncogenic mechanisms

The paper infers a gene regulatory network (GRN) from perturbation experiments in cancer cells, identifying both known and novel regulatory interactions that contribute to oncogenic processes.