PBRM1-Dependent PBAF Targeting is Required for EMT and Metastasis in Breast Cancer
Alisha Dhiman, Mitchell G. Ayers, Jamie L McCuiston, Aparna B. Shinde, Saeed Salehin Akhand, Guanming Jiao, Juan P P Jauregui-Lozano, Marco Hadisurya, Elizabeth G. Poulsen Porter, W. Andy Tao, Vikki Marie Weake, Yucheng Zhang, Sagar M. Utturkar, Matthew R. Marunde, Michael K. Wendt, Emily C. Dykhuizen
This study shows that PBRM1 in PBAF is essential for EMT and metastasis in breast cancer by enabling promoter targeting and DNA accessibility for TGFβ1-inducible genes.
Science Advances · Jul 29, 2026Peer-reviewedMolecular Biology