Author

Michael K. Wendt

Purdue University West LafayetteORCID 0000-0002-3665-7413Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alisha DhimaniD· 2 shared Aparna B. ShindeiD· 1 shared Brittany L. Allen-PeterseniD· 1 shared Brittany N. HeiliD· 1 shared Chenglong LiiD· 1 shared Chittaranjan DasiD· 1 shared Daniel Patrick FlahertyiD· 1 shared Elizabeth G. Poulsen PorteriD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMolecular Biology

Alisha DhimanORCID

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Author profile →

3 papers

Recent·Most cited

PBRM1-Dependent PBAF Targeting is Required for EMT and Metastasis in Breast Cancer

Alisha Dhiman, Mitchell G. Ayers, Jamie L McCuiston, Aparna B. Shinde, Saeed Salehin Akhand, Guanming Jiao, Juan P P Jauregui-Lozano, Marco Hadisurya, Elizabeth G. Poulsen Porter, W. Andy Tao, Vikki Marie Weake, Yucheng Zhang, Sagar M. Utturkar, Matthew R. Marunde, Michael K. Wendt, Emily C. Dykhuizen

This study shows that PBRM1 in PBAF is essential for EMT and metastasis in breast cancer by enabling promoter targeting and DNA accessibility for TGFβ1-inducible genes.

Science Advances · Jul 29, 2026Peer-reviewedMolecular Biology

Identification, optimization, and structural elucidation of chloroacetamide scaffold as covalent inhibitors for Ubiquitin C-terminal Hydrolase L3

Nagabhushana C. Beeralingappa, Mengyao Lu, Rishi S. Patel, Nipuni M. Pannala, Alisha Dhiman, Brittany N. Heil, Ryan D. Imhoff, Emily G. Smith, Mei B Bahler, Haley L Marsden, Brittany L. Allen-Petersen, Mike Wendt, Chittaranjan Das, Daniel Patrick Flaherty

This study identifies and optimizes a chloroacetamide scaffold as a covalent inhibitor for UCHL3, supported by structural and biochemical validation.

bioRxiv · May 29, 2026 · PreprintPharmacology & Toxicology

CDHu40: a novel marker gene set of neuroendocrine prostate cancer (NEPC)

Sheng Liu, Hye Seung Nam, Ziyu Zeng, Xuehong Deng, Elnaz Pashaei, Yong Zang, Lei Yang, Chenglong Li, Jiaoti Huang, Michael K. Wendt, Xin Lü, Rong Huang, Jun Wan

The paper identifies a novel marker gene set, CDHu40, for neuroendocrine prostate cancer (NEPC) using gene expression and PPI network analysis, showing strong prognostic significance.

Briefings in Bioinformatics · Sep 10, 2024Peer-reviewedBioinformatics