Author

Thomas N. Perry

Centre National de la Recherche ScientifiqueORCID 0000-0001-7314-2884Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Assay:protein structure· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

C. Axel InnisiD· 2 shared Agata D. MisiaszekiD· 1 shared Alba Herrero del ValleiD· 1 shared Alessandro VanniniiD· 1 shared Allyson K. Martínez· 1 shared Andrea GraziadeiiD· 1 shared Anne‐Xander van der SteliD· 1 shared Arnab SenguptaiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMolecular Biology

C. Axel InnisORCID

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3 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedJan 2, 2025

Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters

Syed Zawar Shah, Thomas N. Perry, Andrea Graziadei…·Alessandro Vannini

The paper presents cryo-EM structures of the SNAPc-containing Pol III PIC on the U6 snRNA promoter and identifies structural differences in SNAPc engagement between Pol III and Pol II PICs.

7 citations

structural biologyexperimental assay

𝕏 PostBluesky

Molecular BiologyNature Chemical BiologyPeer-reviewedJun 15, 2023

Tetracenomycin X sequesters peptidyl-tRNA during translation of QK motifs

Elodie Leroy, Thomas N. Perry, Thibaud T. Renault, C. Axel Innis

The paper identifies how tetracenomycin X inhibits bacterial translation by sequestering peptidyl-tRNA at QK motifs, revealing a novel mechanism for antibiotic action.

22 citations

bacteria (other)proteomics

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Molecular BiologyNature CommunicationsPeer-reviewedSep 9, 2021

Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome stalling

Anne‐Xander van der Stel, Emily R. Gordon, Arnab Sengupta…·C. Axel Innis

The paper investigates how the TnaC-ribosome complex recognizes and responds to L-Trp, revealing a mechanism involving cleavage rates and ligand binding.

55 citations

E. coliprotein structure

𝕏 PostBluesky