Author

François R. Girardin

Centre Hospitalier Universitaire VaudoisORCID 0000-0002-0842-927XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Aimable NahimanaiD· 1 shared Amarande Murisier· 1 shared Andréanne LupieniD· 1 shared Anthony Vocat· 1 shared Axel Bellotti· 1 shared Benedetta Cena· 1 shared Benoit GueryiD· 1 shared Carine Bardinet· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperPharmacology & Toxicology

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2 papers

Recent·Most cited

Pharmacology & ToxicologyEMBO Molecular MedicinePeer-reviewedOct 7, 2026

Human prostaglandin reductases dearomatize and inactivate benzothiazinone antitubercular drugs

Myriam Briki, Caroline Wagner, Vincent Desfontaine…·Laurent Arthur Decosterd

The paper shows human prostaglandin reductases PTGR1 and PTGR2 inactivate the antitubercular drug MCZ by dearomatizing it into H2MCZ, reducing its antimycobacterial activity.

DOI 10.1038/s44321-026-00526-1

humanexperimental assay

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Genetic & Genomic MedicinemedRxivPreprintAug 19, 2026

Comparative evaluation of genotyping and low-pass sequencing for pharmacogenetic variant and phenotype inference

Flavia Hodel, Christian Wandall Thorball, David Haefliger…·François R. Girardin

This study compares genotyping arrays and low-pass whole-genome sequencing for pharmacogenetic variant and phenotype inference, finding high concordance but improved variant coverage with LP-WGS.

DOI 10.64898/2026.08.18.26360694

humanwhole-genome sequencing

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