Author

Axel Bellotti

Centre Hospitalier Universitaire Vaudois

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Abdelmadjid Atrih· 1 shared Abigail Gaffar· 1 shared Aimable NahimanaiD· 1 shared Amarande Murisier· 1 shared Andréanne LupieniD· 1 shared Anthony Vocat· 1 shared Audrey M. MicheliD· 1 shared Benedetta Cena· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Abdelmadjid Atrih

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Human prostaglandin reductases dearomatize and inactivate benzothiazinone antitubercular drugs

Myriam Briki, Caroline Wagner, Vincent Desfontaine, Anthony Vocat, Onya Opota, Sarah Abou-Zite, Océane Corpataux, Benedetta Cena, Sylvie Guinchard, François Versace, Amarande Murisier, Thomas Mercier, Emilyne Blattes, Carine Bardinet, Paul Thoueille, , Laurent Arthur Decosterd

The paper shows human prostaglandin reductases PTGR1 and PTGR2 inactivate the antitubercular drug MCZ by dearomatizing it into H2MCZ, reducing its antimycobacterial activity.

EMBO Molecular Medicine · Oct 7, 2026Peer-reviewedPharmacology & Toxicology

An integrated stress response-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translation

Mónica Román-Trufero, Istvan T. Kleijn, Kevin Blighe, Jinglin Zhou, Paula Saavedra-García, Abigail Gaffar, Marilena Christoforou, Axel Bellotti, Joel M. Abrahams, Abdelmadjid Atrih, Douglas J. Lamont, Marek Gierliński, Pooja Jayaprakash, Audrey M. Michel, Eric Ofori Aboagye, , Holger W. Auner

This study identifies an ISR-independent role of GCN2 in preventing excessive ribosome biogenesis and mRNA translation, with implications for cancer therapy.

Life Science Alliance · Mar 3, 2025Peer-reviewedCancer Biology