Angiotensin-(1-5) is a Potent Endogenous Angiotensin AT2-Receptor Agonist
Igor Maciel Souza Silva, A. Augusto Peluso, Khalid Elsaafien, Antonina L. Nazarova, Kasper Bostlund Assersen, Lucas Rodrigues‐Ribeiro, Mazher Mohammed, André Felipe Rodrigues, Arkadiusz Nawrocki, Lene Andrup Jakobsen, Pia Jensen, Annette D. de Kloet, Eric G. Krause, Mark P. Del Borgo, Ivan O. Maslov, , U. Muscha Steckelings
This study identifies angiotensin-(1-5) as a potent endogenous agonist of the AT2-receptor, showing its ability to increase nitric oxide release and lower blood pressure through AT2R-mediated mechanisms.
bioRxiv · Apr 5, 2024 · PreprintPharmacology & Toxicology