Arkadiusz Nawrocki

STEP-PTMs: Sequential TMT-based Enrichment and Profiling of Post-Translational Modifications

STEP-PTM enables integrated quantitative analysis of proteome, metabolome, and multiple PTM classes from single biological samples using a modular TMT-multiplexed workflow.

GPMAW Glyco-Search: An Integrated Workflow for Identification and Validation of Intact Sialylated N-Glycopeptides

This paper introduces GPMAW glyco-search, a workflow for high-confidence identification of intact sialylated N-glycopeptides using TiO2 enrichment, dual LC-MS/MS, and interactive spectrum validation, achieving over 2800 identifications in human plasma.

Protein-state dysregulation and sex-specific neurodevelopmental signatures in schizophrenia forebrain organoids

This study uses forebrain organoids to show that schizophrenia involves sex-specific protein-state dysregulation, with changes in post-translational modifications and proteomic pathways rather than transcript levels.

Dysregulation of miRNAs Drives Premature GABAergic Maturation and Early Neurodevelopmental Defects in Schizophrenia

This study uses brain organoids to show that miRNA dysregulation in schizophrenia leads to premature GABAergic maturation and neurodevelopmental defects.

MrgD Receptor Modulates Neurotransmission in the Nigrostriatal Pathway

This study identifies MrgD's role in modulating neurotransmission in the nigrostriatal pathway through proteomic analyses and behavioral assays, revealing impaired synaptic exocytosis and altered behavior in MrgD-deficient mice.

Angiotensin-(1-5) is a Potent Endogenous Angiotensin AT2-Receptor Agonist

This study identifies angiotensin-(1-5) as a potent endogenous agonist of the AT2-receptor, showing its ability to increase nitric oxide release and lower blood pressure through AT2R-mediated mechanisms.