Jie Wu

The paper introduces UbSeRP to map co-translational ubiquitination across the translatome, revealing RQC substrates, biophysical features predicting RQC, and aging-related changes in CTU.

This study shows that tRNA modifications affect codon pair decoding, leading to ribosome stalling and triggering quality control responses to prevent protein aggregation.

This paper introduces a rapid ribosome profiling protocol for low-input samples, reducing RNA input to 0.1 pmol and enabling high-quality data from small samples.

This study shows that cycloheximide affects ribosome profiling data differently in yeast and human cells, suggesting that CHX may not be necessary for accurate human ribosome profiling.