Wendy Lee

Diacylglycerol Kinases Balance DAG Signaling to Control B Cell Maturation, Germinal Center Homeostasis, and Humoral Immunity

This study shows that diacylglycerol kinases regulate B-cell development and humoral immunity by modulating DAG signaling, with distinct effects on GC B-cell homeostasis and antibody responses.

TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway

The paper identifies small molecules that induce a cofactor switch in TEAD proteins from YAP to VGLL4, repressing pro-growth gene networks and showing anti-proliferative effects.

A Domain-Specific Language Model Approach for Identifying Immunogenic Epitopes from Publicly Available Data: EpitopeMiner

EpitopeMiner identifies immunogenic epitopes using a domain-specific LLM with RAG, improving retrieval of relevant literature and supporting neoantigen validation.

Analysis of archaic human haplotypes suggest 5-hmC to act as epigenetic guide for meiotic point recombination

The paper analyzes archaic human haplotypes to show 5-hmC marks guide meiotic point recombination towards functionally relevant genomic regions.