Author

Bibiana Bielekova

National Institutes of HealthORCID 0000-0002-0959-9430Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Alan Thomas RemaleyiD· 1 shared Audrey E. ThurmiD· 1 shared Avi Z. RosenbergiD· 1 shared Benjamin H. SchwarziD· 1 shared Cathryn L. HaighiD· 1 shared Clayton W. WinkleriD· 1 shared Cole D. KimzeyiD· 1 shared Danielle SpringeriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Alan Thomas RemaleyORCID

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2 papers

Recent·Most cited

Proteasome mutations associated with CANDLE syndrome cause altered neuronal development by dysregulating polyamine synthesis

Clayton W. Winkler, Benjamin H. Schwarz, Katie Williams, Sara Alehashemi, Simote Totauhelotu Foliaki, Joseph Snow, Lisa A. Joseph, Audrey E. Thurm, Kip Friend, Gwendolyn Cooper, Eric Bohrnsen, Farzana Bhuyan, Nathan T. Brandes, Ruin Moaddel, Manfred Boehm, , Karin E. Peterson

This study shows that proteasome mutations in CANDLE syndrome disrupt neuronal development by increasing polyamine levels through ODC dysregulation, and inhibiting ODC can reverse these effects.

Journal of Clinical Investigation · Aug 4, 2026Peer-reviewedNeuroscience

Apolipoprotein-L1 G1 variant contributes to hydrocephalus but not to atherosclerosis in apolipoprotein-E knock-out mice

Teruhiko Yoshida, Zhi-Hong Yang, Shinji Ashida, Zu‐Xi Yu, Shashi Shrivastav, Krishna Vamsi Rojulpote, Piroz Bahar, David Nguyen, Danielle Springer, Jeeva Munasinghe, Matthew F. Starost, Victoria J. Hoffmann, Avi Z. Rosenberg, Bibiana Bielekova, Han Wen, , Jeffrey B. Kopp

The paper investigates the role of APOL1 variants in cardiovascular and neurological diseases using mice, finding APOL1-G1 contributes to hydrocephalus but not atherosclerosis.

Clinical Science · Jun 1, 2025Peer-reviewedMolecular Biology