Jeeva Munasinghe

Clinical, in vitro, and in vivo evidence of WAPL as a novel cohesinopathy gene and phenotypic driver of 10q22.3q23.2 genomic disorder

The paper identifies WAPL as a novel cohesinopathy gene and driver of a genomic disorder, showing its role in developmental delay and other anomalies through clinical, in vitro, and in vivo analyses.

Band-selective IR PRESS for brain tumor spectroscopy allows robust detection of lactate

This paper introduces SPIR-PRESS, a magnetic resonance spectroscopy method that improves lactate detection in brain tumors by reducing lipid interference, showing increased sensitivity and broader metabolite profiling.

Apolipoprotein-L1 G1 variant contributes to hydrocephalus but not to atherosclerosis in apolipoprotein-E knock-out mice

The paper investigates the role of APOL1 variants in cardiovascular and neurological diseases using mice, finding APOL1-G1 contributes to hydrocephalus but not atherosclerosis.

PET by MRI: Glucose Imaging by 13C-MRS without Dynamic Nuclear Polarization by Noise Suppression through Tensor Decomposition Rank Reduction

This paper introduces a method to image glucose metabolism using 13C-MRS with tensor decomposition to enhance signal-to-noise ratio, enabling non-hyperpolarized imaging of the Warburg effect with high temporal and spatial resolution.