Lynette Cegelski

This paper develops antimicrobial polyacrylamides using a cross-molecular machine learning pipeline trained on antimicrobial peptides, showing synergy with clinical drugs against E. coli biofilms.

The paper shows that the K5 capsular polysaccharide of E. coli Nissle 1917 sensitizes it to thioridazine and related antipsychotics, revealing CPS as a vulnerability under non-antibiotic drug pressure.

The paper shows glycogen phase separation in E. coli causes asymmetric division and macromolecular rearrangement during growth phase transition.

This paper develops polyacrylamide-based copolymers as broad-spectrum antibiotics effective against multiple pathogens and shows they can restore the efficacy of existing antibiotics.

This study identifies RbmB as a polysaccharide lyase that cleaves Vibrio cholerae VPS, contributing to biofilm dispersal and suggesting its potential as an antibacterial enzyme.

This study elucidates the molecular mechanism of phosphoethanolamine (pEtN) modification and secretion of cellulose in Enterobacteriaceae, identifying key protein interactions and enzymatic roles.