Alessio Fragasso

Spatial control of karyopherin binding avidity within NPC mimics revealed by designer FG-Nucleoporins

This study designs and tests artificial FG-Nups to show that spacing and charge-to-hydrophobicity ratio affect Kap95 binding and transport selectivity through NPCs.

Cross-Molecular Active Learning for the Discovery of Antimicrobial Polyacrylamides

This paper develops antimicrobial polyacrylamides using a cross-molecular machine learning pipeline trained on antimicrobial peptides, showing synergy with clinical drugs against E. coli biofilms.

Glycogen phase separation drives macromolecular rearrangement and asymmetric division in Escherichia coli

The paper shows glycogen phase separation in E. coli causes asymmetric division and macromolecular rearrangement during growth phase transition.

Time-resolved phenotyping at subcellular resolution reveals shared principles and key trade-offs across antimicrobial peptide activities

The paper develops a time-resolved single-cell pipeline to analyze antimicrobial peptides in E. coli, revealing two classes with opposing functional trade-offs in their mechanisms and efficacy against biofilms.

Coupling of cell growth modulation to asymmetric division and cell cycle regulation in Caulobacter crescentus

This study shows that Caulobacter crescentus daughter cells have different growth rates due to a G1 phase slowdown, mediated by (p)ppGpp, linking growth modulation to asymmetric division and cell cycle regulation.

Dynamin A as a one-component division machinery for synthetic cells

This study demonstrates that Dynamin A can split dumbbell-shaped liposomes, functioning as a one-component division machinery for synthetic cells.

A synthetic membrane shaper for controlled liposome deformation

This paper introduces a DNA-based tool called SMS to generate controlled liposome shapes like stomatocytes and dumbbells, compatible with protein reconstitution.