Author

Christopher Pastore

University of PennsylvaniaORCID 0000-0002-1002-6138Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

De’Broski R. HerbertiD· 3 shared Karl Herbine· 2 shared Li Yin Hung· 2 shared Yingbiao Ji· 2 shared Yun Wei· 2 shared Adriana StephensoniD· 1 shared Audrey C. BrowniD· 1 shared Camila M. NapuriiD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

De’Broski R. HerbertORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

REGULATION OF COLONIC MACROPHAGES AND TYPE-17 AND REGULATORY T CELLS IN DSS-COLITIS BY IBD-ASSOCIATED TRANSCRIPTION FACTOR, CREM

Shelby L. Schenck, Md Jashim Uddin, Christopher Pastore, Audrey C. Brown, William A. Petri

This study shows that global deletion of CREM reduces DSS-colitis severity by increasing colonic macrophages and regulatory T cells.

bioRxiv · Jan 27, 2026 · PreprintImmunology

TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni.

Juan Manuel Inclan-Rico, Adriana Stephenson, Camila M. Napuri, Heather Lynn Rossi, Li‐Yin Hung, Christopher Pastore, Wenqin Luo, De’Broski R. Herbert

This study shows that TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni by regulating immune cell responses and limiting parasite dissemination.

The Journal of Immunology · Aug 7, 2025Peer-reviewedImmunology

LINGO3 interacts with Trefoil factor 2 to enforce mucosal barrier integrity and drive tissue repair during colitis

Kelly M. Zullo, Yingbiao Ji, Yun Wei, Karl Herbine, Nicole Maloney, Rachel Cohen, Christopher Pastore, Ma Samsouk, Sriram Srivatsa, Li Yin Hung, Michael H. Kohanski, Noam A. Cohen, De’Broski R. Herbert

This study identifies LINGO3 as a novel receptor for TFF2 that is essential for maintaining mucosal barrier integrity and tissue repair during colitis.

bioRxiv · Nov 13, 2018 · PreprintCell Biology

TFF3 is a ligand for LINGO2 that de-represses EGFR to control disease outcome during colitis and gastrointestinal nematode infection

Yingbiao Ji, Yun Wei, JoonHyung Park, Li Yin Hung, Tanner Young, Karl Herbine, Taylor Oniskey, Christopher Pastore, Wildaliz Nieves, Ma Somsouk, De’Broski R. Herbert

This study identifies TFF3 as a ligand for LINGO2 that de-represses EGFR, influencing disease outcomes in colitis and nematode infection.

bioRxiv · Nov 13, 2018 · PreprintCell Biology