De’Broski R. Herbert

This study shows that sensory neuron subsets differentially modulate psoriasiform inflammation by shaping γδ T cell effector programs.

The study shows CD14 is critical for pain and inflammation in post-traumatic osteoarthritis and that blocking CD14 can reduce pain and mobility loss.

This study shows trained ILC2s prevent IL-17-driven lung injury during helminth re-infection via a serotonin-dependent mechanism, distinct from TH2 cells.

This study shows that TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni by regulating immune cell responses and limiting parasite dissemination.

This study shows that type 1 immunity, via IFNγ signaling, protects intestinal tissue from damage during helminth infection without reducing parasite burden.

This study shows perforin-2 is not essential for antifungal immunity against A. fumigatus and C. albicans in immune-competent mice, emphasizing the need for co-housed littermate controls.

This study shows that Wnt4 is essential for cDC1 commitment and suppresses Type 2 immunity against hookworms.

This study identifies LINGO3 as a novel receptor for TFF2 that is essential for maintaining mucosal barrier integrity and tissue repair during colitis.

This study identifies TFF3 as a ligand for LINGO2 that de-represses EGFR, influencing disease outcomes in colitis and nematode infection.