δ-α cell-to-cell interactions modulate pancreatic islet Ca2+ oscillation modes
Huixia Ren, Yanjun Li, Beichen Xie, Zhenchao Fu, Xiaohong Peng, Weiran Qian, Yi Yu, Tianyi Chang, Xiaojing Yang, Kim Sneppen, Liangyi Chen, Chao Tang
The paper shows that δ-cell interactions modulate pancreatic islet Ca2+ oscillation patterns through somatostatin secretion and pharmacological/optogenetic perturbations, revealing a Hopf bifurcation mechanism.
Cell Systems · Apr 16, 2026Peer-reviewedSystems Biology