Tianyi Chang

The paper shows that δ-cell interactions modulate pancreatic islet Ca2+ oscillation patterns through somatostatin secretion and pharmacological/optogenetic perturbations, revealing a Hopf bifurcation mechanism.

This paper introduces PRISM, a method for high-plex spatial RNA imaging using color intensity barcodes, validated across multiple tissues and showing the role of CAFs in tumor microenvironments.

This study shows serotonin modulates the time window for fear learning by regulating neuronal activity in the ventral hippocampus.

The paper introduces IMPACT, a method to enhance spatial proteomics resolution and sensitivity through tissue compression and optimized digestion, demonstrating improved protein detection and anatomical resolution.

The paper introduces SPRINTseq, a spatial transcriptomics method that enables fast, sensitive, and high-resolution data acquisition, revealing cellular and subcellular molecular architecture in Alzheimer's disease.