Epstein-Barr virus transformation creates a methionine-dependent ferroptosis vulnerability in B cells
Shaowen White, Rui Guo, Bidisha Mitra, Hongdou Li, Shunji Li, Yifei Liao, Rishi Puri, John M. Asara, E.W. Stone, George Georgiou, Benjamin E. Gewurz
This study shows that methionine restriction induces ferroptosis in EBV-transformed B cells by promoting transsulfuration and glutathione synthesis, and that targeting methionine metabolism can impair tumor growth.
bioRxiv · Jul 13, 2026 · PreprintBiochemistry