Robert W. Davies

Interactions with polygenic background impact quantitative traits in the UK Biobank

The paper identifies genetic interactions affecting quantitative traits in the UK Biobank by testing SNP interactions with polygenic scores, finding 144 independent interactions across 52 traits.

Utilizing Non-Invasive Prenatal Test Sequencing Data Resource for Human Genetic Investigation

The paper develops methods for analyzing low-depth NIPT sequencing data to accurately estimate allele frequencies and genetic effect sizes, enabling population genetic studies.

Rapid and accurate genotype imputation from low coverage short read, long read, and cell free DNA sequence

QUILT2 enables accurate genotype imputation from low coverage short and long reads and cell-free DNA, improving GWAS and PRS for maternal and fetal genomes.

The PREGCARE study: Personalized recurrence risk assessment following the birth of a child with a pathogenic de novo mutation

The paper presents a method to assess recurrence risk of de novo mutations in families using deep-sequencing and haplotyping, finding that 59% of DNMs had reduced risk below 0.1%.

Private Genomes and Public SNPs: Homomorphic encryption of genotypes and phenotypes for shared quantitative genetics

This paper introduces a homomorphic encryption method for genotypes and phenotypes to enable privacy-preserving quantitative genetic analysis across studies.