Kyle J. Kinney

UNCOVERseq is a workflow for sensitive off-target nomination in CRISPR-Cas editing, demonstrating superior performance across multiple modalities and systems.

PASTA quantifies chromosomal translocations from amplicon sequencing with high accuracy and sensitivity, outperforming existing methods in detecting rare rearrangements.

This study shows TSST-1 disrupts endothelial regeneration by impairing migration, cytoskeletal organization, and angiogenic sprouting, leading to non-healing vascular lesions.