Liver size is predetermined in the neonate by adding lobules at the periphery
D. Berfin Azizoglu, Karina Perez, Sherry Li Zheng, Shahadat Rahman, Ellen Youngsoo Rim, Teni Anbarchian, Matt Fish, Kyle M. Loh, Kristy Red‐Horse, Roeland Nusse
The paper identifies that neonatal vascularization, specifically angiogenesis in the hepatic vein periphery, determines adult liver size in mice by adding lobules.
Nature Communications · Nov 13, 2025Peer-reviewedDevelopmental Biology