Kristy Red‐Horse

A stem cell-derived human vein-to-artery endothelial conversion model mirrors angiogenesis-derived embryonic arteries; VEGF plus PI3K inhibition alone yields 92% DLL4+CXCR4+ endothelium by 48 hours.

The paper uses Perturb-seq in mice to identify genes that promote collateral artery formation by comparing gene expression between guinea pigs and mice.

This study identifies brain macrophages in the African turquoise killifish that engulf brain extracellular material, showing age-related decline in engulfment capacity.

This study uses 3D imaging to show that mouse placentas invade extensively, requiring CXCL12-CXCR4 signaling, and that disrupting this signaling leads to placenta accreta-like complications.

The paper identifies that neonatal vascularization, specifically angiogenesis in the hepatic vein periphery, determines adult liver size in mice by adding lobules.

The paper identifies a primed endothelial progenitor that requires VEGF/ERK inhibition to differentiate into vein endothelial cells, revealing a two-step process for vein development.

This study identifies EBF1 as a regulator of embryonic artery formation and shows its reactivation in pulmonary arterial hypertension drives pathological vascular remodeling.

This study identifies a biophysical mechanism of SOX18/NR2F2 transcriptional antagonism that governs venous differentiation and shows that inhibiting SOX18 can improve vascular malformation symptoms.

The paper identifies CXCL12 as a genetic driver of coronary artery anatomy variation through GWAS and mouse models, showing its role in fetal coronary development.

This study uses metabolically purified human hepatocytes to show that Ebola and Lassa viruses have distinct effects on liver cells.

This study creates a gene regulation map of the human fetal heart to interpret genetic variants associated with congenital heart disease and cardiac traits, identifying valvular interstitial cells as key regulators.

The paper shows that Dach1's temporal refinement is essential for the transcriptional maturation of somatosensory neurons.

This study identifies de-differentiation and proliferation of artery endothelial cells as key drivers of coronary collateral development in neonatal hearts, which is absent in adults.

The paper shows that coronary endothelial cells in mouse and human hearts initially show lineage-specific transcriptional differences but later become influenced by location, with adult cells becoming more homogeneous.

This study shows that overexpressing Dach1 in endothelial cells extends coronary arteries and improves heart function after myocardial infarction in mice.

This study identifies angiocrine factors secreted by endocardial and endothelial cells that regulate cardiomyocyte development and maturation, contributing to ventricular non-compaction in Ino80-deficient mouse hearts.

On patterned flow cells using exclusion amplification, up to 5-10% of reads are credited to the wrong sample in a pool, traced to free index primers surviving library cleanup.