Lay Teng Ang

Mapping the regulatory wiring of endothelial cell differentiation reveals a critical role for Hippo mechanosignaling

The paper maps gene regulators of endothelial cell differentiation using CRISPR and single-cell RNA-seq, identifying Hippo mechanosignaling as critical for endothelial identity.

Human vein-to-artery endothelial cell fate transition is driven by VEGF/ERK activation and PI3K inhibition

A stem cell-derived human vein-to-artery endothelial conversion model mirrors angiogenesis-derived embryonic arteries; VEGF plus PI3K inhibition alone yields 92% DLL4+CXCR4+ endothelium by 48 hours.

Discovery of a primed endothelial progenitor that requires VEGF/ERK inhibition to complete vein differentiation

The paper identifies a primed endothelial progenitor that requires VEGF/ERK inhibition to differentiate into vein endothelial cells, revealing a two-step process for vein development.

Egyptian rousette bat macrophages elicit divergent interferon responses and cytokine storm signalling against Marburg and Sudan viruses

This study compares macrophage responses to Marburg and Sudan viruses in Egyptian rousette bats, revealing divergent interferon and cytokine storm signaling pathways.

Metabolically purified human stem cell-derived hepatocytes reveal distinct effects of Ebola and Lassa viruses

This study uses metabolically purified human hepatocytes to show that Ebola and Lassa viruses have distinct effects on liver cells.

Dach1 extends artery networks and protects against cardiac injury

This study shows that overexpressing Dach1 in endothelial cells extends coronary arteries and improves heart function after myocardial infarction in mice.

Accelerated human liver progenitor generation from pluripotent stem cells by inhibiting formation of unwanted lineages

This study accelerates the generation of human liver progenitors from pluripotent stem cells by blocking unwanted lineage formation and manipulating temporal signals.