Dextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy
Tao Zheng, Keerthana Ramanathan, Maria Ormhøj, Mikkel Rasmus Hansen, Hólmfridur R. Halldórsdóttir, Hanxi Li, Kamilla Kjærgaard Munk, Carlos Rodriguez Pardo, Rasmus U. W. Friis, Islam Seder, Peter M. H. Heegaard, Klaus Qvortrup, Hinrich Abken, Yi Sun, Sine Reker Hadrup
This paper introduces T-Expand, a dextran-based nanoparticle system for T cell expansion that enhances CAR T cell efficacy and reduces manufacturing complexity.
Nature Communications · Jan 20, 2026Peer-reviewedImmunology