Author

Sam Michael

National Institutes of HealthORCID 0000-0002-1070-6563Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Anton M. SimeonoviD· 2 shared Carlos A. TristaniD· 2 shared Claire WeberiD· 2 shared Ilyas SingeçiD· 2 shared Jaroslav SlameckaiD· 2 shared Pei‐Hsuan Chu· 2 shared Pinar OrmanogluiD· 2 shared Seungmi RyuiD· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersDevelopmental Biology

Anton M. SimeonovORCID

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3 papers

Recent·Most cited

Directed Differentiation of Human Pluripotent Stem Cells into Radial Glia and Astrocytes Bypasses Neurogenesis

Vukasin M. Jovanovic, Claire Weber, Jaroslav Slamecka, Seungmi Ryu, Pei‐Hsuan Chu, Chaitali Sen, Jason M. Inman, Juliana Ferreira de Sousa, Elena S. Barnaeva, Marissa B. Hirst, David Galbraith, Pinar Ormanoglu, Yogita Jethmalani, J Colon, Sam Michael, , Ilyas Singeç

This paper develops a method to efficiently generate astrocytes from human pluripotent stem cells by bypassing neurogenesis, validated through multiple assays and adapted for drug modeling.

Stem Cell Reports · Jul 13, 2023Peer-reviewedDevelopmental Biology

Retro Drug Design: From Target Properties to Molecular Structures

Yuhong Wang, Sam Michael, Shyh‐Ming Yang, Ruili Huang, Kennie Cruz-Gutierrez, Yaqing Zhang, Jinghua Zhao, Menghang Xia, Paul Shinn, Hongmao Sun

This paper introduces retro drug design (RDD), an AI method to generate novel small molecule drugs with desired properties, and demonstrates its ability to produce compounds with biological activity and BBB permeability.

Journal of Chemical Information and Modeling · Jun 2, 2022Peer-reviewedBioinformatics

A Comprehensive Roadmap of Human Placental Development in vitro

Jaroslav Slamecka, Carlos A. Tristan, Seungmi Ryu, Pei‐Hsuan Chu, Claire Weber, Tao Deng, Yeliz Gedik, Pinar Ormanoglu, Sam Michael, Ty C. Voss, Anton M. Simeonov, Ilyas Singeç

This study develops methods to efficiently generate placental cell types from human pluripotent stem cells and validates their characteristics using multi-omics analyses.

bioRxiv · Apr 7, 2022 · PreprintDevelopmental Biology