Chengjie Zhou

Hierarchical chromatin polyvalency governs robust gene regulation and organogenesis

The paper shows that H2Aub, not H3K27me3, is the main repressor in chromatin polyvalency, and its disruption causes organogenesis defects in mouse embryos.

Rescue schizophrenia-related phenotypes caused by Setd1a deficiency by histone demethylase inhibitors

This study identifies TAK-418 as a histone demethylase inhibitor that rescues schizophrenia-like phenotypes in Setd1a-deficient mice by restoring H3K4me3 levels and gene expression.

Subcellularly Resolved 3D Translatome in Mouse Oocytes and Early Embryos

The paper profiles the subcellularly resolved 3D translatome in mouse oocytes and early embryos, revealing spatially controlled translation patterns and embryo asymmetry.

Decoding stage-specific functions of PRC2 uncovers a cell-autonomous role in preimplantation development and a non-cell-autonomous role in primordial germ cell fate

This study reveals stage-specific PRC2 functions in preimplantation development and PGC fate through epigenetic dynamics and intercellular communication.

The transcription factor GABPA is a master regulator of naive pluripotency

This study identifies GABPA as a master regulator of naive pluripotency by showing its role in EPI specification and regulation of 47% of EPI genes during the E3.5 to E4.5 transition.