Author

Lu Chen

Sichuan UniversityORCID 0000-0002-1083-9729Unclaimed ORCID profile · follow to get notified of new preprints

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Lu Chen9 papers · Fudan University

Biology Disciplines

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Bioinformatics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:dimensionality reduction· 1 Research Focus:drug response / drug discovery· 1 Assay:Hi-C· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

Yuan WangiD· 2 shared Bi‐Sen DingiD· 1 shared Hao KongiD· 1 shared Hong JiangiD· 1 shared Hubing ShiiD· 1 shared Jie YangiD· 1 shared Lang CheniD· 1 shared Lunxu LiuiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Yuan WangORCID

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2 papers

Recent·Most cited

An immunomechanical checkpoint PYK2 governs monocyte-to-macrophage differentiation in pancreatic cancer

Wenyan Xie, Xin Yu, Qingxin Yang, Nengwen Ke, Ping Wang, Hao Kong, Xiangji Wu, Panpan Ma, Lang Chen, Jie Yang, Xiuqin Feng, Yuan Wang, Hubing Shi, Lu Chen, Yunhua Liu, , Hong Jiang

This study identifies PYK2 as an immunomechanical checkpoint governing monocyte-to-macrohage differentiation in PDAC, showing its role in mechanotransduction and improved immunotherapy response.

Cancer Discovery · May 8, 2025Peer-reviewedImmunology

Sashimi.py: a flexible toolkit for combinatorial analysis of genomic data

Yiming Zhang, Ran Zhou, Lunxu Liu, Lu Chen, Yuan Wang

Sashimi.py provides a flexible and scalable tool for visualizing genomic data across multiple assays and formats, enabling combinatorial analysis of regulatory mechanisms.

PLoS Computational Biology · Sep 5, 2023Peer-reviewedBioinformatics