Shai Shaham

C. elegans E3 ubiquitin ligase EBAX-1 promotes non-apoptotic linker cell-type death through target-directed miRNA degradation

Non-apoptotic death of the C. elegans linker cell is primed by MYRF-1 activation of pqn-41/polyQ

The paper identifies MYRF-1 as a regulator of non-apoptotic linker cell death in C. elegans, showing its role in priming death through activation of pqn-41/polyQ.

EOR-1/PLZF-regulated WAH-1/AIF sequentially promotes early and late stages of non-apoptotic corpse removal

This study identifies EOR-1/PLZF as a regulator of WAH-1/AIF, which sequentially promotes non-apoptotic corpse removal during development.

Radial-glia-to-astrocyte trans-differentiation and astrocyte transcriptional convergence are coordinated by CEH-43/DLX in C. elegans

The paper identifies CEH-43/DLX as a key regulator of radial-glia-to-astrocyte trans-differentiation in C. elegans and mouse, showing its role in transcriptional convergence.

C. elegans CED-3 caspase promotes non-apoptotic linker cell dismantling but not death onset

The paper shows that CED-3 caspase in C. elegans promotes non-apoptotic linker cell dismantling but not death onset, and reveals similar mechanisms in mouse cells.

Mitochondria transported by Kinesin 3 prevent localized calcium spiking to inhibit caspase-dependent specialized cell death

The paper investigates the role of mitochondrial transport by kinesin motors in preventing localized calcium spiking and caspase-dependent cell death during specialized elimination in C. elegans neurons.

C. elegans LET-381/FoxF and DMD-4/DMRT control development of the mesodermal HMC endothelial cell

The paper identifies LET-381/FoxF and DMD-4/DMRT as regulators of HMC endothelial cell fate in C. elegans.

Glia detect and mount a protective response to loss of dendrite substructure integrity in C. elegans

The paper shows that glia in C. elegans detect and respond to dendrite structure damage by altering gene expression and secreting proteins, with specific proteins required for this response.

Astrocyte-derived extracellular matrix proteins regulate synapse remodeling in stress-induced depression

This study identifies astrocyte-derived extracellular matrix proteins, particularly SPARC, as regulators of synapse remodeling in stress-induced depression.

LET-381/FoxF and UNC-30/Pitx2 control the development of C. elegans mesodermal glia that regulate motor behavior.

This study identifies LET-381/FoxF and UNC-30/Pitx2 as key regulators of C. elegans mesodermal glia development and function, showing their role in motor behavior regulation.

Nucleus-Independent Transgenerational Small RNA Inheritance in C. elegans

This study shows that small RNAs can be inherited transgenerationally in C. elegans without nuclear factors or chromatin changes, mediated by ZNFX-1 and germ granules.

A developmental pathway for epithelial-to-motoneuron transformation in C. elegans

The paper identifies a cell-division-independent pathway for epithelial-to-motoneuron transformation in C. elegans, revealing regulatory mechanisms involving Notch, Ngn, and cytoskeletal genes.

Transgenerational Regulation of Sexual Attractiveness in C. elegans Nematodes

The paper shows that inherited small RNAs in C. elegans regulate sexual attraction and outcrossing rates across generations, influencing population genetics under stress.

Lineage-specific control of convergent differentiation by a Forkhead repressor

The paper identifies UNC-130 as a lineage-specific repressor that enables convergent differentiation in C. elegans by allowing proper specification of glial cells from distinct lineages.

Glia actively sculpt sensory neurons by controlled phagocytosis to tune animal behavior

This study shows that glia actively engulf neuron fragments in C. elegans, affecting neuron shape and thermosensory behavior through a molecular pathway involving PS receptors and GTPase signaling.

C. elegans REMO-1, a glial GPCR, regulates stress-induced nervous system remodeling and behavior

Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5