Christopher A. Brittin

Transient morphogenetic constraints organize self-assembling axon neighborhoods for robust yet flexible wiring

The paper shows how transient morphogenetic structures and stochastic innervation models shape reproducible yet flexible wiring in C. elegans nervous systems through a trade-off between physical constraints and molecular specificity.

Cadherin Preserves Cohesion Across Involuting Tissues During C. elegans Neurulation

This study shows that HMR-1/Cadherin mediates tissue cohesion during C. elegans neurulation, suggesting a potential homology with vertebrate neurulation.

Multicellular rosettes organize neuropil formation

The paper shows multicellular rosettes organize the nerve ring neuropil in C. elegans by guiding axon outgrowth and structural formation.

Beyond the connectome: A map of a brain architecture derived from whole-brain volumetric reconstructions

The paper presents a complete structure-function model of the C. elegans nerve ring by integrating volumetric reconstructions with synaptic and gap junctional connectomes, revealing modular organization and a reference core circuit.

Volumetric reconstruction of main Caenorhabditis elegans neuropil at two different time points

The paper reconstructs the C. elegans nerve ring at two time points and identifies three levels of wiring specificity, suggesting non-spatial factors contribute to synaptic and subcellular specificity.