Daniel A. Colón‐Ramos

The paper shows that coexisting neurotransmitters in C. elegans are differentially regulated by experience and contribute distinctively to behavior.

The paper shows how transient morphogenetic structures and stochastic innervation models shape reproducible yet flexible wiring in C. elegans nervous systems through a trade-off between physical constraints and molecular specificity.

The paper investigates how different forms of autophagy restrict neurite outgrowth in distinct neuronal compartments in C. elegans neurons.

The paper develops and validates a genetically encoded fluorescent sensor, iG6PSnFR, for measuring glucose-6-phosphate dynamics across multiple biological contexts.

SynaptoTagMe enables in vivo mapping and modulation of neurotransmission at single-cell resolution in C. elegans by fluorescently labeling and ablating vesicular transporters.

The paper develops a multisensor framework in C. elegans neurons to study redox constraints on glycolysis, showing that redox state modulates glycolytic activity and neuronal function.

The paper shows how thermosensory neurons in C. elegans use gain modulation based on experience to encode temperature changes relevant for navigation.

The paper engineers an electrical synapse in mice using fish connexins to modulate neural circuits and behavior.

The paper maps physical cell-cell contacts in mouse visual cortex, revealing a dense contactome that exceeds synaptic connectivity and highlights the role of astrocytes in shaping the neural microenvironment.

This paper develops an improved FBP sensor, HYlight2, for in vivo imaging of glycolysis in various organisms.

The paper shows that glycolytic specialization in two C. elegans neurons shapes their biophysical properties and functional roles in vivo.

The paper analyzes mitochondrial morphology and spatial organization in Drosophila neurons to identify systematic rules governing their positioning and cell-type specificity.

The paper investigates tissue-specific metabolic functions of GPI-1 in C. elegans, showing isoform-specific localization and metabolic roles in different tissues.

This study identifies PYGL-1 as essential for glycolytic plasticity in neurons, revealing two mechanisms that support synaptic function under metabolic stress.

The paper introduces NeuroSC, a platform that integrates graph analytics with connectome data to explore neurodevelopmental changes in C. elegans.

The paper uses a biosensor to image glycolysis in individual neurons of C. elegans, revealing diverse and adaptable glycolytic states across cell types and conditions.

The paper shows that blocking programmed cell death in C. elegans leads to extra neurons that alter specific behaviors like reversal frequency and duration.

The paper shows that electrical synapses in C. elegans filter sensory information to guide context-specific behavioral choices by modulating neuronal excitability and integration of temperature stimuli.

This study identifies CLA-1L's role in regulating ATG-9 trafficking and presynaptic autophagy through interactions with endocytic proteins.

The paper identifies neuromodulatory circuits in C. elegans that control sickness behavior dynamics during infection by Pseudomonas aeruginosa.

This study identifies ATG-9 trafficking as a mechanism linking presynaptic autophagy to the synaptic vesicle cycle in C. elegans.

The paper investigates how differential adhesion controls neurite placement in C. elegans brain neuropils through a retrograde zippering mechanism.

The paper develops engineered gap junction hemichannels to enable precise, long-term neural circuit editing in mammals by enabling communication between distinct cell types.

The paper uses diffusion condensation to analyze the C. elegans nerve ring neuropil, revealing its stratified structure and developmental principles.

This study shows that HMR-1/Cadherin mediates tissue cohesion during C. elegans neurulation, suggesting a potential homology with vertebrate neurulation.

The paper shows multicellular rosettes organize the nerve ring neuropil in C. elegans by guiding axon outgrowth and structural formation.

This paper introduces HySyn, a synthetic synapse system that rewires neural circuits in vivo by creating de novo neuromodulatory transmission in C. elegans.

The paper identifies MIG-17, a secreted metalloprotease, as a regulator of synaptic allometry in C. elegans by modifying the extracellular matrix and glia morphology during growth.

The paper shows how two plasticity mechanisms in a single C. elegans neuron encode thermosensory information and actuate a temperature-preference memory.

This study identifies cla-1 as a novel C. elegans active zone gene, showing that specific isoforms regulate synapse development, synaptic vesicle clustering, and release.