Expanding Hippocampal Ensembles through LINE-1 RNA Downregulation Enhances Cognition
Nicole Politowska, Judit Gal Toth, Peter U. Hámor…·Miklós Tóth
This study shows that reducing LINE-1 RNA in hippocampal neurons increases their firing capacity and expands neuronal ensembles, improving spatial memory but reducing pattern separation.