Author

Aline Desmedt

InsermORCID 0000-0002-1179-7161Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alice Shaam Al AbediD· 2 shared Aline MarighettoiD· 2 shared Sophie TroneliD· 2 shared Adeline CathalaiD· 1 shared Anaïs M. DuffaudiD· 1 shared Anne QuiedevilleiD· 1 shared Azza SellamiiD· 1 shared Christophe MulleiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersNeuroscience

Alice Shaam Al AbedORCID

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4 papers

Recent·Most cited

Anterior cingulate cortex engram drives post traumatic stress disorder-like memory impairments in a rodent model of traumatic fear

Flávia Simões, Lorenzo Baltimore, Zora Pelloquin-Mvogo, Laurent Groc, Aline Desmedt, Olivier Nicole, Sophie Tronel

This study identifies the anterior cingulate cortex engram as a key driver of PTSD-like memory impairments in a rodent model of traumatic fear.

bioRxiv · Sep 4, 2026 · PreprintNeuroscience

Stress-induced plasminogen activator inhibitor-1 (PAI-1) as a blood biomarker and brain risk factor for PTSD

Marie Mennesson, S. Abdelkaoui, Valérie Roullot, Sophie Tronel, Adeline Cathala, Valérie Lalanne, Pierre‐Louis Raux, Leila Makrini, Emmanuel Valjent, Anaïs M. Duffaud, Damien Claverie, Monique Vallée, Aline Desmedt, Marion Trousselard, Jean‐Michel Revest

This study identifies PAI-1 as a blood biomarker and brain risk factor for PTSD, showing increased levels in PTSD-like models and soldiers with PTSD symptoms.

Molecular Psychiatry · Mar 30, 2026Peer-reviewedNeuroscience

The correct temporal connectivity of the DG CA3 circuits involved in declarative memory processes depends on Vangl2-dependent planar cell polarity signaling

Noémie Depret, Marie Gleizes, Maïté Marie Moreau, Sonia Poirault‐Chassac, Anne Quiedeville, Steve Dos Santos Carvalho, Vasika Venugopal, Alice Shaam Al Abed, Jérôme Ezan, Gaël Barthet, Christophe Mulle, Aline Desmedt, Aline Marighetto, Claudia Racca, Mireille Montcouquiol, Nathalie Sans

This study identifies Vangl2 as essential for the morphogenesis and function of MfB/TE synapses in the hippocampus and shows its role in declarative memory processes.

Progress in Neurobiology · Feb 15, 2025Peer-reviewedNeuroscience

Parvalbumin Interneuron Activity Underlies Vulnerability to Post-Traumatic Stress Disorder in Autism

Alice Shaam Al Abed, Tiarne Vickie Allen, Noorya Yasmin Ahmed, Azza Sellami, Yovina Sontani, Aline Marighetto, Aline Desmedt, Nathalie Dehorter

This study shows that stress-induced PTSD-like memory worsens ASD traits in mice through hyperactivation of the prefrontal cortex and parvalbumin interneuron dysfunction, and suggests recontextualization as a potential treatment.

bioRxiv · Jan 18, 2021 · PreprintNeuroscience