Laurent Groc

The paper identifies a female-specific microglial redox program that influences susceptibility to obesity by modulating metabolic resilience and mTORC1 signaling.

This study identifies the anterior cingulate cortex engram as a key driver of PTSD-like memory impairments in a rodent model of traumatic fear.

This paper introduces SPoT, a method to track carbon nanotubes in brain tissue to study nanoscale rheological heterogeneity by analyzing translational and rotational dynamics.

This paper introduces a method for nanoscale drift stabilization in thick non-transparent tissues using back-illumination phase imaging and cross-correlation analysis, enabling high-quality imaging of extracellular structures.

This study investigates amyloid plaque penetrability and extracellular space rheology in an AD mouse model using imaging techniques, finding heterogeneous diffusivity and dysregulated extracellular matrix around plaques.

This study identifies type I TARPs as regulators of Kv7.2 potassium channels and shows their role in modulating neuronal excitability and seizure susceptibility.

This study shows that NMDAR autoantibodies disrupt the excitatory-inhibitory balance in the hippocampus, leading to network hypersynchrony and symptoms resembling schizophrenia.

This study shows that restoring glutamate receptosome dynamics in Shank3-deficient mice rescues synaptic and behavioral deficits associated with autism.

The paper shows that CaMKII activation leads to persistent liquid-liquid phase separation with GluN2B, forming stable postsynaptic assemblies that enhance synaptic transmission and memory formation.

This study shows that restoring NMDAR function in adult mice with congenital NMDAR deficiency improves cognitive behaviors, suggesting potential for adult treatment of related disorders.