Yan Zhu

This study identifies P2x2 receptor upregulation in the cochlea as a cause of hyperacusis, showing that antagonists can reduce hearing hypersensitivity.

The paper introduces native MOWChIP-seq, a low-input ChIP-seq method, and applies it to study protein binding differences between mouse brain regions.

This study shows that elevated extracellular K+ causes inner hair cell ribbon synapse degeneration, similar to noise-induced synaptopathy, and suggests BK channels as a potential therapeutic target.

This study shows that MOC efferent nerves also innervate cochlear supporting cells, modulating gap junctions and affecting OHC electromotility, which impacts hearing sensitivity and noise protection.