Julien Courchet

This study shows that perinatal hypoxia leads to persistent transcriptional and structural changes in cortical neurons, resulting in altered connectivity and behavioral deficits in adult mice.

The paper develops an automated workflow for whole brain analysis of neuronal activity using c-Fos immunohistochemistry and open-source tools, enabling accurate and unbiased quantification across contexts.

This study compares pre- and post-mortem perfusion methods for tissue fixation, finding differences in axonal structures, mitochondrial morphology, and immunostaining quality.

This study identifies NUAK1 as a regulator of alternative splicing in cortical neurons through phosphorylation of SON, linking it to neurodevelopmental processes and ZTTK syndrome.

The paper identifies de novo monoallelic DDX17 variants in 11 patients with neurodevelopmental disorders and shows DDX17 dysfunction causes neuronal migration and axon outgrowth defects in multiple models.

This study shows Nav1 regulates neuritogenesis by promoting growth cone macropinocytosis and actin dynamics, linking it to neurotrophin signaling and neural development.

This study shows NUAK1 regulates cortical axon branching by modulating mitochondrial metabolism and positioning, with functional rescue observed through mitochondrial function upregulation.

This study shows that haploinsufficiency of the autism candidate gene Nuak1 in mice causes cortical development defects and behavioral abnormalities resembling ASD, intellectual disability, and schizophrenia.