Author

James S. Griffiths

King's College LondonORCID 0000-0002-7147-2465Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Julian R. NaglikiD· 2 shared A. Reed· 1 shared Adrian Lau· 1 shared Aize PellóniD· 1 shared Alexander KempfiD· 1 shared Anand ShahiD· 1 shared Andrew J. Donkin· 1 shared Darius P. H. Armstrong-JamesiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

Julian R. NaglikORCID

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2 papers

Recent·Most cited

The IL-1 Family Controls Acute Mucosal Fungal Infection and Mucosal-Systemic Dissemination.

James S. Griffiths, Alexander Kempf, Robert J. Pickering, Emily L. Priest, Olivia K. A. Paulin, Léa Lortal, Andrew J. Donkin, Olivia W. Hepworth, Don N. Wickramasinghe, Aize Pellón, Adrian Lau, Harun Papini, Sarah L. Gaffen, Jonathan P. Richardson, Julian R. Naglik

This study shows the IL-1 family is essential for mucosal defense against Candida albicans, preventing infection and dissemination, but its absence in neutropenic conditions leads to fatal systemic infection.

bioRxiv · Apr 10, 2026 · PreprintMicrobiology

Selective targeting of IL-1RAP-dependent eosinophilic inflammation in allergic fungal airway disease

Thomas J Williams, James S. Griffiths, Luis Edgardo Gonzales-Huerta, David Bell, A. Reed, Anand Shah, Julian R. Naglik, Darius P. H. Armstrong-James

This study identifies IL-1RAP as a target for reducing eosinophilia in allergic fungal airway disease using a mouse model of chronic A. fumigatus exposure.

Allergy · Feb 11, 2026Peer-reviewedImmunology