Author

Mathieu Laplante

Institut universitaire de cardiologie et de pneumologie de QuébecORCID 0000-0002-1752-6741Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Chantal GarandiD· 2 shared Romain DevillersiD· 2 shared Sabine EloweiD· 2 shared Suparba RoyiD· 2 shared Adeline GouletiD· 1 shared Aishwarya Atakkatan· 1 shared Aishwarya MageshiD· 1 shared Alexis DuringeriD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

Chantal GarandORCID

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Author profile →

4 papers

Recent·Most cited

An Itch Receptor Drives Melanoma

Naina Gour, Aishwarya Atakkatan, Moloud Akbarzadeh, Hwan Mee Yong, Aishwarya Magesh, Zhiping Wu, Hyunkeun Joo, Yash Chhabra, Junmin Peng, Ashani T. Weeraratna, Mathieu Laplante, Stéphane Lajoie, Xinzhong Dong

This study identifies MRGPRX4 as a melanoma driver that promotes invasion, therapy resistance, and an immunosuppressive tumor microenvironment.

bioRxiv · Sep 20, 2026 · PreprintCancer Biology

ZNF768 regulates expression of E2F1 protein to drive G0/G1 transition and cell cycle progression.

Romain Devillers, Benjamin Brisebois, Suparba Roy, Emeline I. J. Lelong, Audrey Poirier, Alona Kolnohuz, Danielle Caron, Christophe Tav, Romain Villot, Frédéric Lessard, Laura Tribouillard, Chantal Garand, Arnaud Droit, Samer M. I. Hussein, Philippe Joubert, , Sabine Elowe

This study identifies ZNF768 as a regulator of E2F1 expression, which drives G0/G1 transition and cell cycle progression, with implications for cancer progression.

bioRxiv · Aug 4, 2026 · PreprintCell Biology

ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression

Diogjena Katerina Prifti, Annie Lauzier, Chantal Garand, Eva Calvo, Romain Devillers, Suparba Roy, Alexsandro dos Santos, Laurence Descombes, Benjamin Trudel, Mathieu Laplante, François Bordeleau, Sabine Elowe

This study shows TEM4 regulates the cell cycle by controlling G1 progression through modulation of p21waf1/cip1 and cyclin B levels.

The Journal of Cell Biology · Dec 11, 2024Peer-reviewedCell Biology

Versatile and robust genome editing with Streptococcus thermophilus CRISPR1-Cas9

Daniel Agudelo, Sophie Carter, Minja Velimirovic, Alexis Duringer, Jean-François Rivest, Sébastien Levesque, Jérémy Loehr, Mathilde Mouchiroud, Denis Cyr, Paula J. Waters, Mathieu Laplante, Sylvain Moineau, Adeline Goulet, Yannick Doyon

This paper engineers CRISPR-Cas9 variants from Streptococcus thermophilus to target diverse A-rich PAMs, enabling efficient genome editing in mice.

bioRxiv · Jul 31, 2019Molecular Biology