Cell BiologyStem Cell Research & TherapyPeer-reviewed
SAHA increases chaperone expression and reduces Z-alpha-1-antitrypsin polymers in a patient specific iPSC-based liver model for alpha-1-antitrypsin deficiency
Nina Graffmann, Rabea Hokamp, Christiane Loerch…·James Adjaye
The paper uses iPSC-derived liver cells to show SAHA reduces Z-alpha-1-antitrypsin polymers by increasing chaperone expression in AATD models.
DOI 10.1186/s13287-026-05365-y