Author

Colin Eric Willoughby

University of UlsterORCID 0000-0002-1246-4166Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Research Focus:GWAS / association mapping· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Srinivasan SenthilkumariiD· 3 shared Ramasamy Krishnadas· 2 shared Ravinarayanan HaribalaganeshiD· 2 shared Alex William HewittiD· 1 shared Anastasia GurinovichiD· 1 shared Andrew John LoteryiD· 1 shared Anthony J. GriswoldiD· 1 shared Anthony P. KhawajaiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersGenetic & Genomic Medicine

Srinivasan SenthilkumariORCID

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Author profile →

4 papers

Recent·Most cited

Pharmacogenomics of steroid-induced ocular hypertension: relationship to high-tension glaucomas and new pathophysiologic insight

Zeyuan Song, Satyabrata Pany, Shengru Guo, Arpan G. Mazumder, Tatsuo Itakura, Jonathan Huang, Evan Magarychoff, Anastasia Gurinovich, Penelope H. Benchek, William Daniel Stamer, Francis W. Price, Colin Eric Willoughby, Srinivasan Senthilkumari, Ronnie Jacob George, Srujana Chitipothu, , M. Elizabeth Fini

The paper identifies 44 SNPs associated with steroid-induced ocular hypertension using a pharmacogenomic approach.

Ophthalmology Science · May 21, 2026Peer-reviewedGenetic & Genomic Medicine

Step change in glaucoma polygenic risk score performance enables clinical utility and disease prediction across all major ancestries

Stuart MacGregor, Guiyan Ni, Mathias Seviiri, Antonia Kolovos, Ngoc‐Quynh Le, Mark Hassall, Joshua M. Schmidt, Puya Gharahkhani, Victoria Tang, Emmanuelle Souzeau, Ayub Qassim, Priyanka Nandakumar, Suyash Shringarpure, Julie M. Granka, Jessica N. Cooke Bailey, , Jamie E. Craig

This paper develops a polygenic risk score for glaucoma with improved performance across major ancestries, enabling earlier detection and targeted treatment of high-risk individuals.

medRxiv · Jan 24, 2026 · PreprintGenetic & Genomic Medicine

Hsa-MiR-483 -3p Regulates the Extracellular Matrix Proteins via TGFbeta2/SMAD4 Signaling in the Glucocorticoid-responsive Human Trabecular Meshwork Cells

Ravinarayanan Haribalaganesh, Rajendrababu Sharmila, Ramasamy Krishnadas, Colin Eric Willoughby, Srinivasan Senthilkumari

This study shows that miR-483-3p reduces ECM production via SMAD4/TGFβ2 signaling in glucocorticoid-responsive HTM cells, suggesting therapeutic potential for steroid-induced glaucoma.

Cell and Tissue Research · Jun 5, 2025Peer-reviewedCell Biology

A Comparative Genome-wide Transcriptome Analysis of Glucocorticoid Responder and Non-Responder Primary Human Trabecular Meshwork Cells

Kandasamy Kathirvel, Ravinarayanan Haribalaganesh, Ramasamy Krishnadas, Veerappan Muthukkaruppan, Colin Eric Willoughby, Bharanidharan Devarajan, Srinivasan Senthilkumari

This study compares gene expression in GC-responsive and non-responsive HTM cells to identify molecular targets for treating GC-induced ocular hypertension.

Genes · May 15, 2022Peer-reviewedGenomics