Pharmacogenomics of steroid-induced ocular hypertension: relationship to high-tension glaucomas and new pathophysiologic insight

Zeyuan Song; Satyabrata Pany; Shengru Guo; Arpan G. Mazumder; Tatsuo Itakura; Jonathan Huang; Evan Magarychoff; Anastasia Gurinovich; Penelope H. Benchek; William Daniel Stamer; Francis W. Price; Colin Eric Willoughby; Srinivasan Senthilkumari; Ronnie Jacob George; Srujana Chitipothu; Jonathan H. Lass; Sudha K. Iyengar; Stephen G. Schwartz; Anthony J. Griswold; Paola Sebastiani B; Marianne O. Price; M. Elizabeth Fini

doi:10.1016/j.xops.2026.101239

Genetic & Genomic MedicineOphthalmology ScienceMay 21, 2026

Peer-reviewed journal article

Pharmacogenomics of steroid-induced ocular hypertension: relationship to high-tension glaucomas and new pathophysiologic insight

Zeyuan Song iD, Satyabrata Pany, Shengru Guo iD, Arpan G. Mazumder iD, Tatsuo Itakura, Jonathan Huang, Evan Magarychoff iD, Anastasia Gurinovich iD, Penelope H. Benchek iD, William Daniel Stamer iD, Francis W. Price iD, Colin Eric Willoughby iD, Srinivasan Senthilkumari iD, Ronnie Jacob George iD, Srujana Chitipothu iD, Jonathan H. Lass iD, Sudha K. Iyengar iD, Stephen G. Schwartz iD, Anthony J. Griswold iD, Paola Sebastiani B iD, Marianne O. Price iD, M. Elizabeth Fini iD

Abstract

Adverse drug reactions are a frequent cause of worldwide morbidity and mortality. Glucocorticoids (GCs), commonly used to treat inflammatory diseases, alter gene expression with both beneficial and adverse consequences. When used in the eye, GCs cause steroid-induced ocular hypertension (SIOH) in 30-50% of patients, leading to steroid-induced glaucoma. Evidence suggests that predisposition to SIOH is genetically determined. Here we took a pharmacogenomic approach to discover DNA variants associated with SIOH. We identified 44 SNPs of genome-wide significance (p View larger version (58K): org.highwire.dtl.DTLVardef@18a68daorg.highwire.dtl.DTLVardef@1e9f96borg.highwire.dtl.DTLVardef@1f61519org.highwire.dtl.DTLVardef@e335ef_HPS_FORMAT_FIGEXP M_FIG C_FIG

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