Mitsutoshi Setou

Large-scale dimensional behavioral profiling dissociates fear memory from locomotor confounds in mice: The necessity of baseline-normalized metrics

The paper demonstrates that baseline-normalized metrics are essential for accurately interpreting fear memory in mice, showing that conventional freezing scores confound locomotor activity.

Reprogramming of Lipid Metabolism by FLASH Radiotherapy Selectively Protects Radiosensitive Normal Tissues

This study investigates how FLASH radiotherapy reprograms lipid metabolism to protect radiosensitive normal tissues compared to conventional radiotherapy.

UBL3 UBL domain exhibits distinct helix-centered dynamic control among ubiquitin-like proteins

This study analyzes the dynamic structure of UBL3's UBL domain using computational methods, revealing high flexibility in its C-terminal region and highlighting the role of central helix residues in dynamic control.

UBL3 interaction with α-synuclein is downregulated by silencing MGST3

The paper identifies MGST3 as a key regulator that downregulates the UBL3-α-syn interaction, with oxidative stress also contributing to this effect.

UBL3 Interacts with Alpha-synuclein in Cells and the Interaction is Downregulated by the EGFR Pathway Inhibitor Osimertinib

This study shows UBL3 interacts with alpha-synuclein in cells and this interaction is reduced by osimertinib treatment.