A genome-wide CRISPR screen identifies the glycosylation enzyme DPM1 as a modifier of DPAGT1 deficiency and ER stress
Hans M. Dalton, Raghuvir Viswanatha, Roderick Brathwaite, Jae Sophia Zuno, Alexys R. Berman, Rebekah Rushforth, Stephanie Elizabeth Mohr, Norbert Perrimon, Clement Y. Chow
The paper identifies DPM1 as a therapeutic target for DPAGT1-CDG by showing its inhibition rescues ER stress and glycoprotein levels in Drosophila models.
PLoS Genetics · Sep 27, 2022Peer-reviewedGenetics