Joseph M. Rogers

De novo macrocyclic peptide discovery produces potent class A GPCR ligands with diverse pharmacology

This study discovers potent, selective macrocyclic peptide ligands for CXCR4, a class A GPCR, demonstrating the feasibility of de novo peptide design for this receptor family.

A deep learning-generated hASIC1a miniprotein inhibitor confers neuroprotection in stroke

This paper designs a deep learning-generated hASIC1a inhibitor that reduces infarct volume by over 50% in a mouse stroke model.

Proteome-scale quantification of the interactions driving condensate formation of intrinsically disordered proteins

This study develops a high-throughput method to quantify interactions driving condensate formation in intrinsically disordered proteins and shows amino acid content primarily determines partitioning behavior.