Nicola Romanò

The duration of chronic restraint stress protocols does not predict effect sizes in behavioural tests: a meta-analysis

This meta-analysis examines whether the duration of chronic restraint stress affects behavioral test outcomes in rats, finding no correlation between duration and effect sizes.

Differential control of corticotroph Ca2+ signalling by corticotrophin-releasing hormone and arginine vasopressin

The paper quantifies Ca2+ responses in rat corticotrophs to CRH and AVP, showing AVP elicits stronger and faster responses while CRH modulates input integration.

Reporting and justification of sample size in translational chronic variable stress procedures: A systematic review

This study reviews CVS procedures and finds that only one of 385 studies used a biologically meaningful effect size to determine sample size, suggesting poor adherence to the Reduction principle of the Three Rs.

Rodent chronic variable stress procedures: a disjunction between stress entity and impact on behaviour

This study examines how variations in chronic variable stress procedures affect behavioral outcomes in mice, finding that longer and more diverse stress regimens reduce effect sizes in certain tests.

Dynamic transcriptional heterogeneity in pituitary corticotrophs

This study investigates transcriptional heterogeneity in corticotrophs using scRNA-seq, finding that they transition between transcriptional states rather than existing as fixed subpopulations.

Arterial cells support the development of human hematopoietic progenitors in vitro via secretion of IGFBP2.

The paper identifies IGFBP2 as a key factor secreted by arterial cells that enhances hematopoietic progenitor development in vitro.

Single cell transcriptome analysis reveals markers of naive and lineage-primed hematopoietic progenitors derived from human pluripotent stem cells.

The paper identifies markers of naive and lineage-primed hematopoietic progenitors from hPSCs using single-cell RNA sequencing and functional assays.