Author

Robbert M. Spaapen

SanquinORCID 0000-0002-1329-8606Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1

Frequent Co-Authors

Manfred WuhreriD· 2 shared Nordin D. ZandhuisiD· 2 shared S. Marieke van HamiD· 2 shared Tamara VerkerkiD· 2 shared Aimee SelteniD· 1 shared Anouk T. Pappot· 1 shared Antonius A. de WaardiD· 1 shared Arie Johan HoogendijkiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersImmunology

Manfred WuhrerORCID

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2 papers

Recent·Most cited

ImmunologyEuropean Journal of ImmunologyPeer-reviewedDec 10, 2024

Tumor-expressed SPPL3 supports innate anti-tumor immune responses.

Tamara Verkerk, Antonius A. de Waard, Sofie J. I. Koomen…·S. Marieke van Ham

This study shows that SPPL3 in tumor cells affects innate immune responses by modulating nsGSLs, reducing susceptibility to neutrophils, NK cells, and γδ T cells.

3 citations

experimental assaymechanistic / dynamical model

𝕏 PostBluesky

ImmunologybioRxivPreprintOct 13, 2024

nsGSLs on tumors impair anti-tumor immune responses by OT-I T cells in vitro and support tumor growth in vivo

Tamara Verkerk, Aimee Selten, Nordin D. Zandhuis…·S. Marieke van Ham

This study shows that tumor-expressed nsGSLs impair OT-I T cell activation in vitro and promote tumor growth in vivo by evading immune responses.

DOI 10.1101/2024.10.13.617339

mouseexperimental assay

𝕏 PostBluesky