Nordin D. Zandhuis

This study shows that deleting both ZFP36L1 and ZFP36L2 in T cells greatly increases cytokine production but reduces cell viability and signaling.

This study shows that SPPL3 in tumor cells affects innate immune responses by modulating nsGSLs, reducing susceptibility to neutrophils, NK cells, and γδ T cells.

This study shows that tumor-expressed nsGSLs impair OT-I T cell activation in vitro and promote tumor growth in vivo by evading immune responses.

This study shows ZFP36L2 regulates IFNγ production in T cells differently depending on activation context and time, by destabilizing Ifng mRNA in an AU-rich element-dependent manner.