Author

Diego A. Orellana

University of California, San FranciscoORCID 0000-0002-1337-8630Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:metagenomics· 2 Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

José U. ScheriD· 2 shared Peter James TurnbaughiD· 2 shared Rebecca B. BlankiD· 2 shared Renuka R. NayakiD· 2 shared Alexandra L. DegraeveiD· 1 shared Andrew D. PattersoniD· 1 shared Chloe M. Heath· 1 shared Darren S. DumlaoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

José U. ScherORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintMar 30, 2026

Multi-cohort Analysis Reveals Microbiome Signatures Associated with Drug Response in New-Onset Rheumatoid Arthritis

Rahul Bodkhe, Rebecca B. Blank, Kai R. Trepka…·Renuka R. Nayak

The paper analyzes microbiome data from multiple cohorts to identify consistent signatures associated with methotrexate response in rheumatoid arthritis patients.

DOI 10.64898/2026.03.30.715090

humanmetagenomics

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Pharmacology & ToxicologybioRxivPreprintJun 26, 2025

The gut microbiome shapes pharmacology and treatment outcomes for a key anti-inflammatory therapy

Vanya Sofia Villa Soto, Alexandra L. Degraeve, Chloe M. Heath…·Renuka R. Nayak

This study shows that the gut microbiome affects methotrexate pharmacology in mice and contributes to interindividual variation in drug metabolism and treatment outcomes.

4 citations

mousehuman

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