Author

Chloe M. Heath

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

Alexandra L. DegraeveiD· 1 shared Andrew D. PattersoniD· 1 shared Darren S. DumlaoiD· 1 shared Diego A. OrellanaiD· 1 shared Erin R. ReillyiD· 1 shared Jacob G. Brockert· 1 shared José U. ScheriD· 1 shared Judith F. AshouriiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPharmacology & Toxicology

Alexandra L. DegraeveORCID

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Author profile →

1 paper

Recent·Most cited

The gut microbiome shapes pharmacology and treatment outcomes for a key anti-inflammatory therapy

Vanya Sofia Villa Soto, Alexandra L. Degraeve, Chloe M. Heath, Diego A. Orellana, Erin R. Reilly, Mohana Mukherjee, Jacob G. Brockert, Darren S. Dumlao, Rebecca B. Blank, Noah Perlmutter, Steven Yu, Judith F. Ashouri, José U. Scher, Andrew D. Patterson, Peter James Turnbaugh, Renuka R. Nayak

This study shows that the gut microbiome affects methotrexate pharmacology in mice and contributes to interindividual variation in drug metabolism and treatment outcomes.

bioRxiv · Jun 26, 2025 · PreprintPharmacology & Toxicology