Author

Alexandra L. Degraeve

UCLouvainORCID 0009-0002-7388-9579Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:metagenomics· 1

Frequent Co-Authors

Andrew D. PattersoniD· 1 shared Audrey M. NeyrinckiD· 1 shared Axelle E. LoriotiD· 1 shared Camille LefevreiD· 1 shared Chloe M. Heath· 1 shared Darren S. DumlaoiD· 1 shared Diego A. OrellanaiD· 1 shared Edwige PironiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPharmacology & Toxicology

Andrew D. PattersonORCID

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2 papers

Recent·Most cited

Gut microbiota-dependent phenylpropanoic acid derivatives reduced in cancer cachexia protect against myotube atrophy

Alexandra L. Degraeve, Xiaolin Li, Camille Lefevre, Edwige Piron, Axelle E. Loriot, Nathalie M. Delzenne, Audrey M. Neyrinck, Laure B. Bindels

The paper identifies gut microbiota-derived metabolites that protect against muscle atrophy in cancer cachexia by restoring amino acid homeostasis through the serine biosynthesis pathway.

bioRxiv · Sep 18, 2026 · PreprintMicrobiology

The gut microbiome shapes pharmacology and treatment outcomes for a key anti-inflammatory therapy

Vanya Sofia Villa Soto, Alexandra L. Degraeve, Chloe M. Heath, Diego A. Orellana, Erin R. Reilly, Mohana Mukherjee, Jacob G. Brockert, Darren S. Dumlao, Rebecca B. Blank, Noah Perlmutter, Steven Yu, Judith F. Ashouri, José U. Scher, Andrew D. Patterson, Peter James Turnbaugh, Renuka R. Nayak

This study shows that the gut microbiome affects methotrexate pharmacology in mice and contributes to interindividual variation in drug metabolism and treatment outcomes.

bioRxiv · Jun 26, 2025 · PreprintPharmacology & Toxicology